PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort.

doi:10.1016/j.lungcan.2017.07.039

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Article

PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2017

Sawa Kenji, Koh Yasuhiro, Kawaguchi Tomoya, Kambayashi Satoshi, Asai Kazuhisa, Mitsuoka Shigeki, Kimura Tatsuo, Yoshimura Naruo, Yoshimoto Naoki, Kubo Akihito, Saka Hideo, Matsumura Akihide, Wanibuchi Hideki, Yamamoto Nobuyuki, Nishiyama Noritoshi, Hirata Kazuto

Abstract excerpt

OBJECTIVES: Non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) have been proposed to have a mutual developmental mechanism, but their association has not been fully understood. We aimed to examine the association of the mutational landscape of NSCLC with co-morbid COPD. MATERIALS AND METHODS: A total of 197 surgical specimens of early stage NSCLC were retrospectively collected...

Topics

Aged
Aged, 80 and over
Alleles
Biomarkers
Carcinoma, Non-Small-Cell Lung
Class I Phosphatidylinositol 3-Kinases
DNA Mutational Analysis
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Mutation Rate

Neoplasm Staging

Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed

Identifiers

PMID: 29191607
DOI: 10.1016/j.lungcan.2017.07.039

Provenance

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