Article
Targeting driver mutations in lung cancer with interstitial pneumonia: A nationwide study in Japan.
European journal of cancer (Oxford, England : 1990) - 25 Feb 2026
Ikeda Satoshi, Ogura Takashi, Misumi Toshihiro, Nishioka Yasuhiko, Hashimoto Seishu, Ichikado Kazuya, Fukuizumi Aya, Takata Saori, Itoh Taku, Sato Yuki, Okishio Kyoichi, Yatera Kazuhiro, Sakamoto Noriho, Kato Motoyasu, Kikuchi Ryota, Honda Takayuki, Hashimoto Naozumi, Murakami Koji, Isshiki Takuma, Yamane Mayuka, Karayama Masato, Miyamoto Atsushi, Ishida Yuriko, Inomata Minehiko, Nishikiori Hirotaka, Yamaguchi Kakuhiro, Amimoto Hisanori, Tamura Kentaro, Yanagihara Toyoshi, Tanino Yoshinori, Koyama Junji, Tsurumaki Nozomu, Waseda Yuko, Kishaba Tomoo, Ozasa Hiroaki, Matsumoto Masaru, Kinoshita Yoshiaki, Nakamura Yutaro, Yamauchi Hiroyoshi, Kishi Kazuma
Abstract excerpt
INTRODUCTION: Non-small cell lung cancer (NSCLC) patients with comorbid interstitial pneumonia (IP) are at high risk for drug-induced pneumonitis, and previous reports suggest a lower frequency of common driver mutations such as EGFR. This may discourage genetic testing, potentially overlooking prevalent, targetable mutations like KRAS, BRAF, and MET. This study aimed to elucidate the real-world status of genetic...
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