Article
Paired genetic analysis by next-generation sequencing of lung cancer and associated idiopathic pulmonary fibrosis.
Cancer science - 1 Jul 2020
Otsubo Kohei, Iwama Eiji, Ijichi Kayo, Kubo Naoki, Yoneshima Yasuto, Inoue Hiroyuki, Tanaka Kentaro, Osoegawa Atsushi, Tagawa Tetsuzo, Nakanishi Yoichi, Okamoto Isamu
Abstract excerpt
The pathogenesis of lung cancer associated with idiopathic pulmonary fibrosis (IPF) has remained largely uncharacterized. To provide insight into this condition, we undertook genomic profiling of IPF-associated lung cancer as well as of adjacent fibrosing lung tissue in surgical specimens. Isolated DNA and RNA from 17 IPF-associated non-small cell lung cancer and 15 paired fibrosing lung tissue specimens were...
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