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Article

Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis.

International journal of cancer - 15 Jun 2021

Hata Atsushi, Nakajima Takahiro, Matsusaka Keisuke, Fukuyo Masaki, Nakayama Manabu, Morimoto Junichi, Ito Yuki, Yamamoto Takayoshi, Sakairi Yuichi, Rahmutulla Bahityar, Ota Satoshi, Wada Hironobu, Suzuki Hidemi, Iwata Takekazu, Matsubara Hisahiro, Ohara Osamu, Yoshino Ichiro, Kaneda Atsushi

Abstract excerpt

Patients with idiopathic pulmonary fibrosis (IPF) are at higher risk of developing lung cancers including squamous cell lung carcinoma (SCC), which typically carries a poor prognosis. Although the molecular basis of cancer development subsequent to IPF has not been fully investigated, we recently reported two epigenetic phenotypes characterized by frequent and infrequent DNA hypermethylation in SCC, and an...

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PMID: 33533494
DOI: 10.1002/ijc.33499

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