Article

Antisense lncRNA transcription promotes A-to-I RNA editing via intermolecular dsRNA in breast cancer

2026-03-27

Abstract excerpt

A-to-I RNA editing, catalysed by ADAR enzymes, is the most prevalent post-transcriptional RNA modification in mammals, yet the regulatory inputs shaping cell-type-specific editomes remain incompletely understood. Here we characterise over 2.2 million unique A-to-I editing sites across MCF7 (ER+) and MDA-MB-231 (triple-negative) breast cancer cell lines and 117 patient tumours. MCF7 exhibited substantially more edi...

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Literature Corpus work: 2a6d5c58-1420-59a9-b4f4-43039991be62
DOI: 10.64898/2026.03.25.714158

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