Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.

doi:10.1038/s41388-020-01606-3

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Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.

Oncogene - 1 Feb 2021

Varešlija Damir, Ward Elspeth, Purcell Siobhan P, Cosgrove Nicola S, Cocchiglia Sinéad, O'Halloran Philip J, Charmsaz Sara, Bane Fiona T, Brett Francesca M, Farrell Michael, Cryan Jane, Beausang Alan, Hudson Lance, Turnbul Arran K, Dixon J Michael, Hill Arnold D K, Priedigkeit Nolan, Oesterreich Steffi, Lee Adrian V, Sims Andrew H, Redmond Aisling M, Carroll Jason S, Young Leonie S

Abstract excerpt

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1 promotes estrogen receptor (ER) transcriptional activity to enhance cell proliferation. The function of the coactivator in ER+ metastasis however is not established. Here we describe AIB1 as a survival factor,...

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Identifiers

PMID: 33420368
DOI: 10.1038/s41388-020-01606-3
PMCID: PMC7892341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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