Article
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.
Nucleic acids research - 9 Jul 2021
Jin Xiaofeng, Qing Shi, Li Qian, Zhuang Hui, Shen Liliang, Li Jinhui, Qi Honggang, Lin Ting, Lin Zihan, Wang Jian, Cao Xinyi, Yang Jianye, Ma Qi, Cong Linghua, Xi Yang, Fang Shuai, Meng Xiaodan, Gong Zhaohui, Ye Meng, Wang Shuyun, Wang Chenji, Gao Kun
Abstract excerpt
Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high genomic instability, but the underlying mechanisms causing this phenotype are still largely unknown. Here, we report that upon DNA damage, SPOP is phosphorylated at Ser119 by the ATM serine/threonine kinase, which potentiates the binding of...
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