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Article

CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.

The Prostate - 1 Jan 2021

Zhu Yini, Wen Jiling, Huang Gang, Mittlesteadt Jackson, Wen Xiaofei, Lu Xin

Abstract excerpt

BACKGROUND: Recent genomic profiling has identified a subtype of prostate cancer (PCa) characterized by two key genetic alterations: missense mutation of speckle-type POZ protein (SPOP) and homozygous deletion of chromodomain helicase DNA-binding protein 1 (CHD1). Mutually exclusive with E26 transformation-specific (ETS) rearrangements, this subtype displays high genomic instability. Previous studies indicate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33022763
DOI: 10.1002/pros.24080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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