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Article

Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2014

García-Flores María, Casanova-Salas Irene, Rubio-Briones José, Calatrava Ana, Domínguez-Escrig José, Rubio Luis, Ramírez-Backhaus Miguel, Fernández-Serra Antonio, García-Casado Zaida, López-Guerrero José Antonio

Abstract excerpt

AIMS: Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor recently described to be mutated in prostate cancer (PCa). Hence, studying the gene expression profile and the presence of SPOP mutations in PCa and understanding its clinico-pathological significance as prognostic and therapeutic biomarker are important to further understand its role in PCa development. PATIENTS AND METHODS: A cohort of 265...

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Source

Identifiers

PMID: 25204806
DOI: 10.1016/j.ejca.2014.08.009

Genes

SPOP
ERG
TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer.PMID 25204806Read ↗

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Prognostic and Predictive Role of SPOP Mutations in Prostate Cancer: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation.Semantic proximity Read ↗

The emerging role of speckle-type POZ protein (SPOP) in cancer development.Semantic proximity Read ↗

Deregulation of SPOP in Cancer.Semantic proximity Read ↗

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Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate CancerSemantic proximity Read ↗

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