Article
SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Molecular cancer - 5 Aug 2021
Jiang Qiwei, Zheng Nana, Bu Lang, Zhang Xiaomei, Zhang Xiaoling, Wu Yuanzhong, Su Yaqing, Wang Lei, Zhang Xiaomin, Ren Shancheng, Dai Xiangpeng, Wu Depei, Xie Wei, Wei Wenyi, Zhu Yasheng, Guo Jianping
Abstract excerpt
BACKGROUND: 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell survival, proliferation, and metabolic homeostasis. Although the regulations to PDK1 downstream substrates such as protein kinase B (AKT) and ribosomal protein S6 kinase beta (S6K) have been well established, the upstream regulators of PDK1,...
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