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Article

SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.

Molecular biology of the cell - 15 Mar 2020

Watanabe Ryuta, Maekawa Masashi, Hieda Miki, Taguchi Tomohiko, Miura Noriyoshi, Kikugawa Tadahiko, Saika Takashi, Higashiyama Shigeki

Abstract excerpt

SPOP, speckle-type POZ protein is a substrate adaptor protein of the Cullin-3/RING ubiquitin E3 complex. The spop gene is the most commonly point mutated in human primary prostate cancers, but the pathological contribution of the SPOP mutations remains unclear. In this study, we investigated several known factors that are critical in the DNA--protein cross-link repair process. The depletion of SPOP or...

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Identifiers

PMID: 31967940
DOI: 10.1091/mbc.E19-08-0456
PMCID: PMC7185892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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