Article
A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.
Leukemia - 1 Oct 2021
Gourvest Morgane, De Clara Etienne, Wu Hsin-Chieh, Touriol Christian, Meggetto Fabienne, De Thé Hugues, Pyronnet Stéphane, Brousset Pierre, Bousquet Marina
Abstract excerpt
The most frequent genetic alteration in acute myeloid leukemia (AML) is the mutation of nucleophosmin 1 (NPM1). Yet, its downstream oncogenic routes are not fully understood. Here, we report the identification of one long noncoding RNA (lncRNA) overexpressed in NPM1-mutated AML patients (named LONA) whose intracellular localization inversely reflects that of NPM1. While NPM1 is nuclear and LONA cytoplasmic in...
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