NPM1-rearranged AML: clinical features, molecular pathogenesis, and therapeutic perspectives.

Abstract excerpt

Nucleophosmin 1 (NPM1) gene aberrations are among the most common genetic alterations in acute myeloid leukemia (AML). NPM1 mutations (NPM1c), detected in 30-40% of adult AML cases, are well-characterized and associated with distinct clinical and molecular features. In contrast, NPM1 rearrangements (NPM1-r), involving rare fusion partners such as MLF1, CCDC28A, HAUS1, and RARA, are much less common and have...

Topics

• Nucleophosmin
• Humans
• Leukemia, Myeloid, Acute
• Nuclear Proteins
• Exportin 1 Protein
• Receptors, Cytoplasmic and Nuclear