Article
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.
Nature communications - 15 Jun 2021
Uyanik Burhan, Goloudina Anastasia R, Akbarali Aamir, Grigorash Bogdan B, Petukhov Alexey V, Singhal Sunil, Eruslanov Evgeniy, Chaloyard Jeanne, Lagorgette Lisa, Hadi Tarik, Baidyuk Ekaterina V, Sakai Hiroyasu, Tessarollo Lino, Ryffel Bernhard, Mazur Sharlyn J, Lirussi Frederic, Garrido Carmen, Appella Ettore, Demidov Oleg N
Abstract excerpt
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we show that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all display...
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