Article

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors

2020-09-04

Abstract excerpt

<h4>SUMMARY</h4> Majority of cancers harbor alterations of the tumor suppressor TP53 . However, childhood cancers, including unfavorable neuroblastoma, often lack TP53 mutations despite frequent loss of p53 function, suggesting alternative p53 inactivating mechanisms. Here we show that p53-regulating PPM1D at chromosome 17q22.3 is linked to aggressive tumors and poor prognosis in neuroblastoma. We identified...

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Literature Corpus work: 564a859f-9af0-586f-b313-63a217ad5260
DOI: 10.1101/2020.09.04.283648

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