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Article

Phosphatase Wip1 Masters IL-17-producing Neutrophil-mediated Colitis in Mice.

Inflammatory bowel diseases - 1 Jun 2016

Hu Xuelian, Wang Peng, Du Junfeng, Yang Fan, Tian Yuan, Shen Xiaofei, Yang Tao, Zhang Lianfeng, Zhao Yong

Abstract excerpt

Wild-type p53-induced phosphatase 1 (Wip1) is currently believed to be a promising drug target for cancer therapy. Our recent studies showed that deletion of Wip1 remarkably promoted neutrophil inflammatory response. Whether Wip1 is involved in the regulation of inflammatory bowel disease is unknown. In the present study, we found that Wip1 knockout (KO) mice were more susceptible to colitis induced by dextran...

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Identifiers

PMID: 26950306
DOI: 10.1097/MIB.0000000000000751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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