Article
WIP1 phosphatase as a potential therapeutic target in neuroblastoma.
PloS one - 1 Jan 2015
Richter Mark, Dayaram Tajhal, Gilmartin Aidan G, Ganji Gopinath, Pemmasani Sandhya Kiran, Van Der Key Harjeet, Shohet Jason M, Donehower Lawrence A, Kumar Rakesh
Abstract excerpt
The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins involved in DNA damage response including p53, CHK2, Histone H2AX, and ATM, and it has been shown to be overexpressed or amplified in human cancers including breast and ovarian cancers. We examined WIP1 mRNA levels across multiple tumor types and found the highest levels in breast cancer,...
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