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Article

Pro-tumoural effects of vitamin C supplementation in a zebrafish model for SDHB-associated PPGL.

Endocrine-related cancer - 1 Jan 2026

Miltenburg Jasmijn B, Strijker Niek, Gorissen Marnix, Ten Seldam Femke, van Woerkom Lonneke, Zethof Jan, Kusters Benno, Peitzsch Mirko, Timmers Henri J L M, Dona Margo

Abstract excerpt

Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine, chromaffin cell-derived tumours of the adrenal medulla or paraganglia. Germline pathogenic variants in succinate dehydrogenase subunit B (SDHB) are most prevalent and associated with malignancy and poor prognosis. Treatment options are limited, and therapy development is hindered by knowledge gaps concerning the pathomechanism and lack of...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41404848
DOI: 10.1530/ERC-25-0370

Genes

SDHB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Pro-tumoural effects of vitamin C supplementation in a zebrafish model for SDHB-associated PPGL.PMID 41404848Read ↗

Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas.Semantic proximity Read ↗

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.Semantic proximity Read ↗

Epigenetic and metabolic reprogramming of SDH-deficient paragangliomasSemantic proximity Read ↗

15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germline SDHB and SDHD mutationsSemantic proximity Read ↗

Clinical Practice Guidance: Surveillance for phaeochromocytoma and paraganglioma in paediatric succinate dehydrogenase gene mutation carriersSemantic proximity Read ↗

Succinate dehydrogenase (SDH)‐deficient neoplasiaSemantic proximity Read ↗

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.Semantic proximity Read ↗

Therapeutic Targeting of SDHB-Mutated Pheochromocytoma/Paraganglioma with Pharmacologic Ascorbic Acid.Semantic proximity Read ↗

Clinical implications of the oncometabolite succinate in SDHx ‐mutation carriersSemantic proximity Read ↗

Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings.Semantic proximity Read ↗

The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− ratsSemantic proximity Read ↗

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