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Article

An uncommon [K+(Mg2+)2] metal ion triad imparts stability and selectivity to the Guanidine-I riboswitch.

RNA (New York, N.Y.) - 1 Oct 2021

Trachman Robert J, Ferré-D'Amaré Adrian R

Abstract excerpt

The widespread ykkC-I riboswitch class exemplifies divergent riboswitch evolution. To analyze how natural selection has diversified its versatile RNA fold, we determined the X-ray crystal structure of the Burkholderia sp. TJI49 ykkC-I subtype-1 (Guanidine-I) riboswitch aptamer domain. Differing from the previously reported structures of orthologs from Dickeya dadantii and Sulfobacillus acidophilus, our...

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Identifiers

PMID: 34257148
DOI: 10.1261/rna.078824.121
PMCID: PMC8457001

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