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Article

Discrimination between closely related cellular metabolites by the SAM-I riboswitch.

Journal of molecular biology - 26 Feb 2010

Montange Rebecca K, Mondragón Estefanía, van Tyne Daria, Garst Andrew D, Ceres Pablo, Batey Robert T

Abstract excerpt

The SAM-I riboswitch is a cis-acting element of genetic control found in bacterial mRNAs that specifically binds S-adenosylmethionine (SAM). We previously determined the 2.9-A X-ray crystal structure of the effector-binding domain of this RNA element, revealing details of RNA-ligand recognition. To improve this structure, variations were made to the RNA sequence to alter lattice contacts, resulting in a 0.5-A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20006621
DOI: 10.1016/j.jmb.2009.12.007
PMCID: PMC2822714

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