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Article

A cooperative effect of ligands, Mg2+ ions, and the U6C mutation on the structural dynamics of the SAM-Ⅵ Riboswitch.

The Journal of biological chemistry - 1 Jul 2026

Hu Guodong, Cai Chengfei, Qian Jin, Chen Jianzhong

Abstract excerpt

SAM riboswitches, the most abundant type of riboswitch, are classified into eight classes. SAM-VI differs from all other known SAM riboswitch classes by adopting a unique fold and ligand pocket. To elucidate the cooperative structural dynamic effects of ligands, Mg2+, and the U6C mutation on SAM-VI, we carried out extensive MD simulations totaling 128 μs. Free energy decomposition identified four key nucleotides...

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Identifiers

PMID: 42214674
DOI: 10.1016/j.jbc.2026.113211
PMCID: PMC13314739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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