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Article

Interacting Roles of COMT and GAD1 Genes in Patients with Treatment-Resistant Schizophrenia: a Genetic Association Study of Schizophrenia Patients and Healthy Controls.

Journal of molecular neuroscience : MN - 1 Dec 2021

Kogure Masanobu, Kanahara Nobuhisa, Miyazawa Atsuhiro, Oishi Kengo, Nakata Yusuke, Oda Yasunori, Iyo Masaomi

Abstract excerpt

The projection from dopaminergic neurons to gamma-aminobutyric acid (GABA) interneurons in the prefrontal cortex is involved in the etiology of schizophrenia. The impact of interacting effects between dopamine signals and the expression of GABA on the clinical phenotypes of schizophrenia has not been studied. Since these interactions could be closely involved in prefrontal cortex functions, patients with specific...

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Identifiers

PMID: 34125398
DOI: 10.1007/s12031-021-01866-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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