The endocannabinoid system's genetic polymorphisms in sickle cell anemia patients.

doi:10.1038/s41598-024-76480-0

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The endocannabinoid system's genetic polymorphisms in sickle cell anemia patients.

Scientific reports - 30 Dec 2024

Berti Amanda Cristina Meneguetti, de Castro Vanessa da Silveira Ramos, Arcanjo Gabriela Silva, da Silva Araujo Aderson, Lucena-Araujo Antonio Roberto, Bezerra Marcos André Cavalcanti, Gazarini Lucas, da Silva Danilo Grünig Humberto, Belini-Júnior Edis

Abstract excerpt

Sickle cell anemia (SCA) is a monogenic blood disease with complex and multifactorial pathophysiology. The endocannabinoid system (ECS) could be a candidate for modulating SCA complications, such as priapism, as it has demonstrated an essential role in hematopoiesis, platelet aggregation, and immune responses. We evaluated the association of ECS-related single nucleotide polymorphisms (SNP) (FAAH rs324420, MAGL...

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PMID: 39738165
DOI: 10.1038/s41598-024-76480-0
PMCID: PMC11685638

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