Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

doi:10.1158/1078-0432.CCR-21-0180

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Article

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2021

Loree Jonathan M, Wang Yucai, Syed Muddassir A, Sorokin Alexey V, Coker Oluwadara, Xiu Joanne, Weinberg Benjamin A, Vanderwalde Ari M, Tesfaye Anteneh, Raymond Victoria M, Miron Benjamin, Tarcic Gabi, Zelichov Ori, Broaddus Russell R, Ng Patrick Kwok Shing, Jeong Kang Jin, Tsang Yiu Huen, Mills Gordon B, Overman Michael J, Grothey Axel, Marshall John L, Kopetz Scott

Abstract excerpt

PURPOSE: Mutations in KRAS/NRAS (RAS) predict lack of anti-EGFR efficacy in metastatic colorectal cancer (mCRC). However, it is unclear if all RAS mutations have similar impact, and atypical mutations beyond those in standard guidelines exist. EXPERIMENTAL DESIGN: We reviewed 7 tissue and 1 cell-free DNA cohorts of 9,485 patients to characterize atypical RAS variants. Using an in vitro cell-based assay...

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PMID: 34117033
DOI: 10.1158/1078-0432.CCR-21-0180
PMCID: PMC8364867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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