Article
Prognostic implications of RAS alterations in diverse malignancies and impact of targeted therapies.
International journal of cancer - 15 Jun 2020
Kato Shumei, Okamura Ryosuke, Sicklick Jason K, Daniels Gregory A, Hong David S, Goodman Aaron, Weihe Elizabeth, Lee Suzanna, Khalid Noor, Collier Rachel, Mareboina Manvita, Riviere Paul, Whitchurch Theresa J, Fanta Paul T, Lippman Scott M, Kurzrock Razelle
Abstract excerpt
RAS alterations are often found in difficult-to-treat malignancies and are considered "undruggable." To better understand the clinical correlates and coaltered genes of RAS alterations, we used targeted next-generation sequencing (NGS) to analyze 1,937 patients with diverse cancers. Overall, 20.9% of cancers (405/1,937) harbored RAS alterations. Most RAS-altered cases had genomic coalterations (95.3%, median: 3,...
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