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Article

Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts.

International journal of cancer - 1 Feb 2024

Osterlund Emerik, Ristimäki Ari, Mäkinen Markus J, Kytölä Soili, Kononen Juha, Pfeiffer Per, Soveri Leena-Maija, Keinänen Mauri, Sorbye Halfdan, Nunes Luís, Salminen Tapio, Nieminen Lasse, Uutela Aki, Halonen Päivi, Ålgars Annika, Sundström Jari, Kallio Raija, Ristamäki Raija, Lamminmäki Annamarja, Stedt Hanna, Heervä Eetu, Kuopio Teijo, Sjöblom Tobias, Isoniemi Helena, Glimelius Bengt, Osterlund Pia

Abstract excerpt

BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, co-mutations and prognostic and predictive role. These were compared between mutational groups of mCRC patients collected from three Nordic population-based or real-world cohorts. Pathology...

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Identifiers

PMID: 37724848
DOI: 10.1002/ijc.34733

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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