Article
Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis.
Molecular cancer research : MCR - 1 Apr 2025
Woolley Connor E, Domingo Enric, Fernandez-Tajes Juan, Pennel Kathryn A F, Roxburgh Patricia, Edwards Joanne, Richman Susan D, Maughan Tim S, Kerr David J, Soriano Ignacio, Tomlinson Ian P M
Abstract excerpt
BRAF mutations in colorectal cancer comprise three functional classes: class 1 (V600E) with strong constitutive activation, class 2 with pathogenic kinase activity lower than that of class 1, and class 3 which paradoxically lacks kinase activity. Non-class 1 mutations associate with better prognosis, microsatellite stability, distal tumor location, and better anti-EGFR response. An analysis of 13 colorectal...
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