Article
Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017
Cercek Andrea, Braghiroli Maria Ignez, Chou Joanne F, Hechtman Jaclyn F, Kemeny Nancy, Saltz Leonard, Capanu Marinela, Yaeger Rona
Abstract excerpt
Purpose:NRAS mutations are now routinely included in RAS testing prior to EGFR inhibitor therapy for metastatic colorectal cancer (mCRC). The clinical implications of NRAS mutation beyond lack of response to anti-EGFR therapy, however, are not known. We undertook this study to determine the clinical features and treatment outcomes of patients with NRAS-mutant mCRC.Experimental Design: We reviewed clinical...
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