Article
Increased detection of genetic loci associated with risk predictors of osteoporotic fracture using a pleiotropic cFDR method.
Bone - 1 Jun 2017
Greenbaum Jonathan, Wu Kehao, Zhang Lan, Shen Hui, Zhang Jigang, Deng Hong-Wen
Abstract excerpt
Although GWAS have been successful in identifying some osteoporosis associated loci, the findings explain only a small fraction of the total genetic variance. In this study we use a recently developed novel pleiotropic conditional false discovery rate (cFDR) method to identify novel genetic loci associated with two risk traits for osteoporotic fracture (the clinical outcome and end result of osteoporosis), Height...
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