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Article

Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice

1 May 2021

Abstract excerpt

Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients. Accumulating evidence in animal models and clinical trials has indicated that a rational approach is to inhibit a limited number of transforming growth factor β (TGF-β) family ligands, including GDF8 and activin A,...

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Identifiers

PMID: 34113826
DOI: 10.1016/j.isci.2021.102488

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