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Article

Activin A more prominently regulates muscle mass in primates than does GDF8

28 Apr 2017

Abstract excerpt

Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad TGF-β inhibition suggests another family member negatively regulates muscle mass, and its blockade enhances muscle growth seen with GDF8-specific inhibition. Here we...

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PMID: 28452368
DOI: 10.1038/ncomms15153

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