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Article

LDH‐A negatively regulates dMMR in colorectal cancer

10 Jun 2021

Abstract excerpt

Although immune checkpoint inhibitors (ICIs) have achieved unprecedented success in dMMR tumors, pMMR tumors accounting for 85% of colorectal cancer (CRC) cases remain unresponsive. Lactate dehydrogenase A (LDH-A) is the rate-limiting enzyme that catalyzes the transformation of pyruvate to lactate in the process of glycolysis. We investigated the relationship between LDH-A and dMMR with the purpose of exploring...

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Identifiers

PMID: 34110068
DOI: 10.1111/cas.15020

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