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Article

Development of lactate-related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer.

Cancer medicine - 1 Apr 2023

Tong Zhi, Wang Xinyu, Shi Sanbao, Hou Tiewei, Gao Guangrong, Li Da, Shan Yongqi, Zhang Cheng

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a malignant tumor of the digestive system that contains high levels of immune cells. Lactic acid, a major metabolite, plays a crucial role in tumor development, maintenance, and therapeutic response. However, the prognostic potential and therapeutic biomarker potential of lactate-related genes (LRGs) in CRC patients remain to be elucidated. METHODS: We collected the mRNA...

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Identifiers

PMID: 36776001
DOI: 10.1002/cam4.5682
PMCID: PMC10166923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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