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Article

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.

Nature communications - 18 May 2017

Ji Yapeng, Yang Chuanzhen, Tang Zefang, Yang Yongfeng, Tian Yonglu, Yao Hongwei, Zhu Xi, Zhang Zeming, Ji Jiafu, Zheng Xiaofeng

Abstract excerpt

Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for colorectal cancer (CRC) patients with poor prognosis and relapse. However, the context-dependent metabolic traits of CRCSCs remain poorly elucidated. Here we report that adenylate kinase hCINAP is overexpressed in CRC tissues. Depletion of hCINAP inhibits invasion, self-renewal,...

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Identifiers

PMID: 28516914
DOI: 10.1038/ncomms15308
PMCID: PMC5454382

Genes

LDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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