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LDHA is a direct target of miR‐30d‐5p and contributes to aggressive progression of gallbladder carcinoma

23 Mar 2018

Abstract excerpt

Gallbladder cancer (GBC) is the most general biliary tract malignancy, with poor prognosis due to rapid tumor progression and lack of specific symptoms. Lactate dehydrogenase-A (LDHA) can promote Warburg effect to produce lactate and Adenosine Triphosphate (ATP) in aerobic condition, which contributes to oncogenesis metastasis and drug resistance in various cancers. However, the expression and functional role of...

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PMID: 29569755
DOI: 10.1002/mc.22799

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