Article
FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression.
International journal of clinical and experimental pathology - 1 Jan 2015
Jiang Weihua, Zhou Fei, Li Ning, Li Qi, Wang Liwei
Abstract excerpt
The oncogenic transcription factor forkhead box protein M1 (FOXM1) plays critical roles in gastric cancer (GC) development and progression. However, the underlying mechanisms has not fully demonstrated. Lactate dehydrogenase A (LDHA) is widely overexpressed in a series of cancers and is one of the two subunits of Lactate dehydrogenase (LDH), which is the key glycolytic enzyme and catalyzes the interconversion of...
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