Article
PharmVar GeneFocus: CYP2C9.
Clinical pharmacology and therapeutics - 1 Sept 2021
Sangkuhl Katrin, Claudio-Campos Karla, Cavallari Larisa H, Agundez Jose A G, Whirl-Carrillo Michelle, Duconge Jorge, Del Tredici Andria L, Wadelius Mia, Rodrigues Botton Mariana, Woodahl Erica L, Scott Stuart A, Klein Teri E, Pratt Victoria M, Daly Ann K, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular...
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