Article
PharmVar GeneFocus: CYP4F2.
Clinical pharmacology and therapeutics - 1 Oct 2024
Zubiaur Pablo, Rodríguez-Antona Cristina, Boone Erin C, Daly Ann K, Tsermpini Evangelia Eirini, Khasawneh Lubna Q, Sangkuhl Katrin, Duconge Jorge, Botton Mariana R, Savieo Jessica, Nofziger Charity, Whirl-Carrillo Michelle, Klein Teri E, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This...
Topics
- Humans
- Cytochrome P450 Family 4
- Pharmacogenetics
- Haplotypes
- Alleles
- Genetic Variation
- Pharmacogenomic Variants