Article
PharmVar GeneFocus: CYP2B6.
Clinical pharmacology and therapeutics - 1 Jul 2021
Desta Zeruesenay, El-Boraie Ahmed, Gong Li, Somogyi Andrew A, Lauschke Volker M, Dandara Collet, Klein Kathrin, Miller Neil A, Klein Teri E, Tyndale Rachel F, Whirl-Carrillo Michelle, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus impacts the metabolism or bioactivation of clinically important drugs. Of particular importance are efficacy and safety concerns regarding: efavirenz, which is used for the treatment of HIV type-1 infection; methadone, a mainstay in the...
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