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Article

PharmVar GeneFocus: CYP3A5.

Clinical pharmacology and therapeutics - 1 Dec 2022

Rodriguez-Antona Cristina, Savieo Jessica L, Lauschke Volker M, Sangkuhl Katrin, Drögemöller Britt I, Wang Danxin, van Schaik Ron H N, Gilep Andrei A, Peter Arul P, Boone Erin C, Ramey Bronwyn E, Klein Teri E, Whirl-Carrillo Michelle, Pratt Victoria M, Gaedigk Andrea

Abstract excerpt

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam. Variable CYP3A5 activity is of clinical importance regarding tacrolimus...

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Identifiers

PMID: 35202484
DOI: 10.1002/cpt.2563
PMCID: PMC9399309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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