Article

Pharmacokinetic recall study of Estonian Biobank participants carrying novel genetic variants in CYP2C19 and CYP2D6

2025-07-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: <italic>CYP2C19</italic> and <italic>CYP2D6</italic> collectively account for the hepatic metabolism of approximately 35–40% of clinically used drugs. Their genetic polymorphisms significantly influence drug response, including the risk of adverse drug reactions. However, the genetic basis for interindividual differences remains incompletely understood, with mis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37619ddf-25db-52ca-9819-61f2deaf3eb5
DOI: 10.21203/rs.3.rs-7084648/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacokinetic recall study of Estonian Biobank participants carrying novel genetic variants in CYP2C19 and CYP2D6DOI 10.21203/rs.3.rs-7084648/v1Read

Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across EuropeSemantic proximity Read

PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting.Semantic proximity Read

A Review of the Important Role of CYP2D6 in Pharmacogenomics.Semantic proximity Read

From genes to drugs: CYP2C19 and pharmacogenetics in clinical practiceSemantic proximity Read

Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.Semantic proximity Read

Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes.Semantic proximity Read

Pharmacogenetic testing of CYP2D6, CYP2C19 and CYP2C9 in Denmark: Agreement between publicly funded genotyping tests and the subsequent phenotype classification.Semantic proximity Read

Genetic ancestral patterns in<i>CYP2D6</i>alleles: structural variants, rare variants, and clinical associations in 479,144 UK Biobank genomesSemantic proximity Read

Harnessing Knowledge on Very Important Pharmacogenes CYP2C9 and CYP2C19 Variation for Precision Medicine in Resource-Limited Global Conflict Zones.Semantic proximity Read

Development of an Ancestrally Inclusive Preemptive Pharmacogenetic Testing Panel.Semantic proximity Read

Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens.Semantic proximity Read

CYP2C19 genotype-phenotype correlation: current insights and unanswered questionsSemantic proximity Read