Article
PharmVar GeneFocus: CYP2C19.
Clinical pharmacology and therapeutics - 1 Feb 2021
Botton Mariana R, Whirl-Carrillo Michelle, Del Tredici Andria L, Sangkuhl Katrin, Cavallari Larisa H, Agúndez José A G, Duconge Jorge, Lee Ming Ta Michael, Woodahl Erica L, Claudio-Campos Karla, Daly Ann K, Klein Teri E, Pratt Victoria M, Scott Stuart A, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information...
Topics
- Alleles
- Cytochrome P-450 CYP2C19
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Knowledge Bases
- Pharmacogenetics