Article
PharmVar GeneFocus: CYP1A2-Clinical Impact, Genetic Variation, and Updated Nomenclature.
Clinical pharmacology and therapeutics - 1 Aug 2026
Monostory Katalin, Villapalos Garcia Gonzalo, Koller Dora, Adams Solomon, Bousman Chad A, Tsermpini Evangelia Eirini, Whirl-Carrillo Michelle, Turner Amy J, Lauschke Volker M, Nagy Mohamed, Boone Erin C, Klein Teri E, Zubiaur Pablo, Gaedigk Andrea
Abstract excerpt
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines. The activity of CYP1A2 varies significantly among individuals due to genetic and non-genetic factors. This GeneFocus paper offers an...
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