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Article

Epigenetic Plasticity Enables CNS-Trafficking of EBV-infected B Lymphocytes

9 Jun 2021

Abstract excerpt

Subpopulations of B-lymphocytes traffic to different sites and organs to provide diverse and tissue-specific functions. Here, we provide evidence that epigenetic differences confer a neuroinvasive phenotype. An EBV+ B cell lymphoma cell line (M14) with low frequency trafficking to the CNS was neuroadapted to generate a highly neuroinvasive B-cell population (MUN14). MUN14 B cells efficiently infiltrated the CNS...

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PMID: 34106998
DOI: 10.1371/journal.ppat.1009618

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