Back to search

Article

The spatial landscape of infectious mononucleosis tonsils

2025-10-10

Abstract excerpt

Primary Epstein-Barr virus (EBV) infection remains incompletely understood, particularly in relation to the nature of in vivo latency patterns and their influence on the immune microenvironment. Here, we present the first multiomic single-cell spatial atlas of palatine tonsils from individuals with infectious mononucleosis (IM). We identify rare EBV infection of epithelial cells, challenging the prevailing assump...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ad1dbea8-ddaa-522d-ac55-cf24d7b90374
DOI
10.1101/2025.10.09.681345
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The spatial landscape of infectious mononucleosis tonsilsDOI 10.1101/2025.10.09.681345
An Atlas of Cells in the Human TonsilSemantic proximity
A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infectionSemantic proximity
EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease PathogenesisSemantic proximity
Single‐Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T‐Cell LymphomaSemantic proximity
Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro.Semantic proximity
Detection of latent Epstein-Barr virus gene expression in single-cell sequencing of peripheral blood mononuclear cellsSemantic proximity
Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progressionSemantic proximity
Identification of Host Biomarkers of EBV Latency IIb and Latency IIISemantic proximity
Sp140L Is a Novel Herpesvirus Restriction FactorSemantic proximity
Landscape of Epstein-Barr virus gene expression and perturbations in cancerSemantic proximity
Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomicsSemantic proximity
Sp140L functions as a herpesvirus restriction factor suppressing viral transcription and activating interferon-stimulated genesSemantic proximity
Select a neighboring publication to make it the new centre.