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Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas

21 Nov 2024

Abstract excerpt

BACKGROUND: Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into pathobiology and molecular differences, relevant for classification and targeted therapy. METHODS: Twenty-three EBV- and 15 EBV+ PCNSL, histologically classified as diffuse...

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PMID: 39575767
DOI: 10.1093/neuonc/noae251

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