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Article

Mechanistic insights into the CYP2C19 genetic variants prevalent in the Indian population.

Gene - 5 Jun 2021

Naushad Shaik Mohammad, Vattam Kiran Kumar, Devi Yadamreddy Kanaka Durga, Hussain Tajamul, Alrokayan Salman, Kutala Vijay Kumar

Abstract excerpt

PURPOSE: CYP2C19 metabolizes the antiplatelet and antiepileptic drugs. Any alteration in CYP2C19 activity might influence the therapeutic efficacy. The objective of this study was to identify CYP2C19 variants prevalent in Indians and perform their in silico characterization. METHODS: Infinium global screening array (GSA) was used for CYP2C19 genotyping in 2000 healthy Indians. In addition, we performed in silico...

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PMID: 33766706
DOI: 10.1016/j.gene.2021.145592

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