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Aberrant Stress Granule Dynamics and Aggrephagy in ALS Pathogenesis

30 Aug 2021

Abstract excerpt

Stress granules are conserved cytosolic ribonucleoprotein (RNP) compartments that undergo dynamic assembly and disassembly by phase separation in response to stressful conditions. Gene mutations may lead to aberrant phase separation of stress granules eliciting irreversible protein aggregations. A selective autophagy pathway called aggrephagy may partially alleviate the cytotoxicity mediated by these protein...

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PMID: 34571896
DOI: 10.3390/cells10092247

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