Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly transmitted M. tuberculosis strains are more likely to evolve MDR/XDR and cause outbreaks, but what makes them highly transmitted?

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2021

Alame Emane Amel Kevin, Guo Xujun, Takiff Howard E, Liu Shengyuan

Abstract excerpt

Multi-Drug-Resistant strains of Mycobacterium tuberculosis (MDR-TB) are a serious obstacle to global TB eradication. While most MDR-TB strains are infrequently transmitted, a few cause large transmission clusters that contribute substantially to local MDR-TB burdens. Here we examine whether the known mutations in these strains can explain their success. Drug resistance mutations differ in fitness costs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Disease Outbreaks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Evolution, Molecular

Share to Extensively Drug-Resistant Tuberculosis

Share to Mutation

Share to Mycobacterium tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 34102584
DOI: 10.1016/j.tube.2021.102092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly transmitted M. tuberculosis strains are more likely to evolve MDR/XDR and cause outbreaks, but what makes them highly transmitted?PMID 34102584Read ↗

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung EnvironmentSemantic proximity Read ↗

The epidemic of multidrug resistant tuberculosis in China in historical and phylogenetic perspectives.Semantic proximity Read ↗

Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out.Semantic proximity Read ↗

Emergence and evolution of drug-resistant Mycobacterium tuberculosis in eastern China: A six-year prospective study.Semantic proximity Read ↗

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis.Semantic proximity Read ↗

Transmission and resistome of extremely drug-resistant tuberculosis in Beijing, China: A retrospective population-based epidemiological study.Semantic proximity Read ↗

Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient.Semantic proximity Read ↗

Evolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug ResistanceSemantic proximity Read ↗

Long-term spatiotemporal evolution of drug-resistant Mycobacterium tuberculosis in China.Semantic proximity Read ↗

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.Semantic proximity Read ↗

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Comprehensive genomic analysis of Mycobacterium tuberculosis reveals limited impact of high-fitness genotypes on MDR-TB transmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.