Article
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.
PLoS pathogens - 1 Apr 2023
Zwyer Michaela, Rutaihwa Liliana K, Windels Etthel, Hella Jerry, Menardo Fabrizio, Sasamalo Mohamed, Sommer Gregor, Schmülling Lena, Borrell Sonia, Reinhard Miriam, Dötsch Anna, Hiza Hellen, Stritt Christoph, Sikalengo George, Fenner Lukas, De Jong Bouke C, Kato-Maeda Midori, Jugheli Levan, Ernst Joel D, Niemann Stefan, Jeljeli Leila, Ballif Marie, Egger Matthias, Rakotosamimanana Niaina, Yeboah-Manu Dorothy, Asare Prince, Malla Bijaya, Dou Horng Yunn, Zetola Nicolas, Wilkinson Robert J, Cox Helen, Carter E Jane, Gnokoro Joachim, Yotebieng Marcel, Gotuzzo Eduardo, Abimiku Alash'le, Avihingsanon Anchalee, Xu Zhi Ming, Fellay Jacques, Portevin Damien, Reither Klaus, Stadler Tanja, Gagneux Sebastien, Brites Daniela
Abstract excerpt
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC population in Dar es Salaam, Tanzania over a six-year period, using 1,082 unique patient-derived MTBC whole-genome sequences (WGS) and associated clinical data. We...
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